Trophic factor gene therapy for Parkinson's disease.
Identifieur interne : 000713 ( Main/Exploration ); précédent : 000712; suivant : 000714Trophic factor gene therapy for Parkinson's disease.
Auteurs : Jeffrey H. Kordower [États-Unis] ; Anders BjorklundSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Intercellular Signaling Peptides and Proteins.
- genetics : Parkinson Disease.
- methods : Genetic Therapy.
- chemical , therapeutic use : Intercellular Signaling Peptides and Proteins.
- therapy : Parkinson Disease.
- Gene Transfer Techniques, Humans.
Abstract
Parkinson's disease (PD) is a chronic and progressive neurodegenerative movement disorder for which there is presently no cure. Pharmacological remedies targeting the dopaminergic network are relatively effective at ameliorating motor deficits, especially in the early stages of the disease, but none of these therapies are curative and many generate their own problems. Recent advances in PD research have demonstrated that gene delivery of trophic factors, glial cell line-derived neurotrophic factor (GDNF) and neurturin, in particular, can provide structural and functional recovery in rodent and nonhuman primate models of PD. Similar success has been gleaned in open-label clinical trials, although this has yet to be realized in double-blinded analyses. This work reviews the field of trophic factor gene delivery for PD.
DOI: 10.1002/mds.25344
PubMed: 23390096
Affiliations:
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Le document en format XML
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Kordower</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. jkordowe@rush.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612</wicri:regionArea><wicri:noRegion>Illinois 60612</wicri:noRegion></affiliation></author><author><name sortKey="Bjorklund, Anders" sort="Bjorklund, Anders" uniqKey="Bjorklund A" first="Anders" last="Bjorklund">Anders Bjorklund</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="doi">10.1002/mds.25344</idno><idno type="RBID">pubmed:23390096</idno><idno type="pmid">23390096</idno><idno type="wicri:Area/PubMed/Corpus">000A73</idno><idno type="wicri:Area/PubMed/Curation">000A73</idno><idno type="wicri:Area/PubMed/Checkpoint">000734</idno><idno type="wicri:Area/Ncbi/Merge">003A08</idno><idno type="wicri:Area/Ncbi/Curation">003A08</idno><idno type="wicri:Area/Ncbi/Checkpoint">003A08</idno><idno type="wicri:Area/Main/Merge">000713</idno><idno type="wicri:Area/Main/Curation">000713</idno><idno type="wicri:Area/Main/Exploration">000713</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Trophic factor gene therapy for Parkinson's disease.</title><author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. jkordowe@rush.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612</wicri:regionArea><wicri:noRegion>Illinois 60612</wicri:noRegion></affiliation></author><author><name sortKey="Bjorklund, Anders" sort="Bjorklund, Anders" uniqKey="Bjorklund A" first="Anders" last="Bjorklund">Anders Bjorklund</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gene Transfer Techniques</term><term>Genetic Therapy (methods)</term><term>Humans</term><term>Intercellular Signaling Peptides and Proteins (genetics)</term><term>Intercellular Signaling Peptides and Proteins (therapeutic use)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Intercellular Signaling Peptides and Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genetic Therapy</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Intercellular Signaling Peptides and Proteins</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Transfer Techniques</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a chronic and progressive neurodegenerative movement disorder for which there is presently no cure. Pharmacological remedies targeting the dopaminergic network are relatively effective at ameliorating motor deficits, especially in the early stages of the disease, but none of these therapies are curative and many generate their own problems. Recent advances in PD research have demonstrated that gene delivery of trophic factors, glial cell line-derived neurotrophic factor (GDNF) and neurturin, in particular, can provide structural and functional recovery in rodent and nonhuman primate models of PD. Similar success has been gleaned in open-label clinical trials, although this has yet to be realized in double-blinded analyses. This work reviews the field of trophic factor gene delivery for PD.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Bjorklund, Anders" sort="Bjorklund, Anders" uniqKey="Bjorklund A" first="Anders" last="Bjorklund">Anders Bjorklund</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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